Plant extracts are useful for the control of fungal diseases of plants since many years. The present study was conducted for evaluating the in vitro antifungal activity of aqueous extract of Datura inoxia of family Solanaceae against Alternaria alternata, Curvularia lunata, Fusarium pallidoroseum and Macrophomina phaseolina. Thus Datura inoxia can be used as biofungicide against fungal pathogens of vegetable beans. Preliminary phytochemical analysis of aqueous extract revealed the presence of a alkaloids, saponins, phenols, flavonoids and reducing sugars in all plant parts while glycosides, terpenoids, triterpenoids and Steroids were present in aqueous leaf and stem extracts. Thus the leaf, stem and root extracts of Datura inoxia in distilled water can be exploited for the development of potential antimicrobial agents.

Leptospirosis is a zoonotic illness that can spread quickly, particularly during a period of intense rainfall. It is caused by the bacteria Leptospira. Leptospira interrogans, which has over 200 serovars or serologic variations, is harmful to both people and animals. Leptospirosis is typically contracted by humans from direct contact with the urine of diseased animals or from an environment contaminated with urine. Transmission from person to person happens very infrequently. Leptospirosis can show up as a wide range of clinical symptoms, ranging from a minor ailment that could develop into a dangerous and occasionally fatal condition. Its symptoms can mirror those of a variety of illnesses, including dengue, influenza and other viral hemorrhagic infections. In outbreak situations in particular, it is crucial to make the accurate clinical and laboratory diagnosis as soon as symptoms appear in order to avert severe cases and save lives.