Ruellia prostrata belongs to Acanthaceae family and are perennial creepers with widespread medicinal uses, including analgesic and anti-inflammatory activity. The objective of this study was to determine anti-oxidant activity of ethanol and chloroform extracts from flowers parts of Ruellia species viz. Ruellia prostrate. The presence of these compounds could attribute to the potent anti-oxidant activity of Ruellia prostrata extracts. From this study, it was concluded that Ruellia prostrata could have anti-inflammatory activity. The antioxidant nature of the flower extract was proved from Free radical scavenging was determined by using 1, 1-diphenyl-2-picrylhydrazyl (DPPH), ABTS (2, 2’-azinobis (3ethylbenzthiazoline-6-sulphonic acid), ferric reducing antioxidant power (FRAP), nitric oxide scavenging assay (NO), reducing power, hydroxy radical scavenging assay, superoxide radical scavenging (SOD), hydrogen peroxide radical assay, metal chelating activity as well as phosphomolypdenum assay. From the results obtained, Ruellia prostrate flower extract can be considered as a therapeutic agent for the treatment of free radical mediated diseases.
K. Baskaran*, V. Namitha, A. Safana, M. Abishek, S. Dinesh Raja, Sijo Henry, N. Haseera, Shalet Varghese.
Throughout Africa, Asia, Europe, and North America, Chenopodium album Linn (Family: Chenopodiaceae) is a weed that is aggressively proliferating. This plant has been used as an antiparasitic, diuretic, hepatoprotective, laxative and sedative in folk medicine. Its leaves can be used as a wash or poultice on insect bites, rheumatoid joints, sunburn, and swollen feet because they have antirheumatic, anthelmentic, antiphlogistic, moderately laxative, and odontalogic characteristics. In addition to providing basic nutritional advantages, this plant is grown as a vegetable in India and has tremendous biological potential. The anthelmintic, antipruritic, contraceptive and sperm immobilising effects of this plant have been documented in earlier scientific studies. As a result, this plant has huge potential for thorough biological screening. So, the present study was carried out to assess its phytochemical and antibacterial properties in order to clarify the potential traditional usage of this plant. A methanol extract of Chenopodium album leaves was examined for its ability to inhibit the growth of Bacillus subtilis, Bacillus cereus, Bacillus frimicutes, Escherichia coli, Entrobacter, Klebsiella and other bacteria (both gram-positive and gram-negative bacteria). The extract of Chenopodium album also contained proteins, glycosides, alkaloids, flavonoids, terpenoids, tannins, fixed oil, and lipids. The antibacterial activity were evaluated using the agar disc diffusion method. The outcomes shown that the antibacterial properties of Chenopodium album Linn suppress the growth of microorganisms in a dose-dependent manner. The outcomes demonstrate the antibacterial activity of Chenopodium album extract in the tested environment. Secondary metabolites are thought to be crucially produced by this plant. The results also imply that beneficial outcomes may emerge from scientific studies that regularly make use of herbs with established efficacy claims.
Alka Shukla, S. Karmakar, Priyanka Pandey*, Wasim Raja.
One of the body's most intricate processes is the healing of wounds. Several cell types with different roles during the phases of hemostasis, inflammation, growth, re-epithelialization and remodelling must be coordinated in both space and time. Phenotypic and functional variability within a few of these cell types have been discovered because to the development of single cell technologies. Rare stem cell subgroups that are unipotent in the undamaged state but become multipotent after skin injury have also been found to exist within the skin. Understanding the functions of each of these cell types and how they interact is crucial to comprehending the mechanisms of normal wound closure. The recruitment and activation of cells are directly impacted by changes in the microenvironment, which include modifications to mechanical pressures, oxygen levels, chemokines, extracellular matrix, and growth factor production. This results in conditions of poor wound healing. In order to create efficient therapeutic treatments for healing wounds, single cell technologies can be used to understand these cellular modifications in pathological states including chronic wounds and hypertrophic scarring. This review's goal is to outline the many cellular and molecular components of the skin's healing process.