The use of medicinal plants plays a vital role to maintain the human health. Due to the high demand for traditional medicines, there is a need for continuous research on medicinal plant for their therapeutic effects. Therefore, to investigate the phytochemicals present in the medicinal plants that are responsible for potential pharmacological action is necessary. Artocarpus altilis (family: Moraceae) has been traditionally used by the people in Indonesia to treat various human ailments. The aim of the present study was to determine the total phenolic, tannin and flavonoid contents in A. altilis leaf and fruit extracts. Ethanol and water extracts of A. altilis were prepared by cold maceration method and the extracts were subjected to preliminary phytochemical screening. The phytoconstituents such as carbohydrates and glycosides, proteins and free amino acids, phenolic compounds and tannins, flavonoids, volatile oils and terpenoids were found to be present in the extracts. The total tannin content, phenolic content and flavonoid content were determined by colorimetric method. The results showed that the total phenolic content in A. altilis leaf and fruit extracts ranged from 1.284 to 9.245 (mg Gallic acid equivalents / g dry crude extract) where the total tannin content ranged from 0.239 to 4.499 (mg Gallic acid equivalents / g dry crude extract) and total flavonoid content was ranged from 0.143 to 10.828 (mg Quercetin equivalents / g dry crude extract). The quantitative estimation of this study is a key reference to isolate the phytoconstituents for developing the novel herbal drugs and their standardization.

The aim of the present study was to evaluate anthelminthic activity of crude ethanolic extract of Artocarpus heterophyllus bark by using test worm. Albendazole was included as standard. The results indicated that ethanolic extract was significantly paralysis and also caused death of worm in short time compared to that of the standard drug. Various concentrations like 5, 10, 15, 25, 50mg/ml of ethanolic extract was tested, against the paralysis and death, but 50mg/ml showed less time (03.88±0.19) for paralysis and (23.57±0.38) for death of worm. So we conclude, that the traditional use of Artocarpus heterophyllus has anthelminthic activity and further studies are suggested to isolate the active principles which are responsible for the activity. The observations showed the anthelminthic activity of Artocarpus heterophyllus by paralysis and death of earth worms.

In the present study was to explore the protective effect Pterostilbene (PTSB) on plasma lipid peroxidation, antioxidant status (In-vivo) and free radical scavenging property (In-vitro) against sodium fluoride (NaF) induced toxicity in rats. In this investigation sodium fluoride (25 mg/kg BW) was administrated intragastrically for 4 weeks to induce toxicity. Pterostilbene (PTSB) was administrated orally (40 mg/ kg BW) for 4 weeks along with sodium fluoride. The toxic effect of fluoride was indicated by the elevated levels of lipid peroxidation and significantly decreased activities of non-enzymatic antioxidants like GSH, Vit.C and E in the plasma of rats. Administration of PTSB revealed a significant (p<0.05) decreased in lipid peroxidation with a significant (p<0.05) increase antioxidant status in plasma of fluoride treated rats. Using of PTSB with five different concentrations (10, 20, 30, 40, and 50 µM) free radical scavenging activity was evaluated by following in vitro assays such as 1,1-diphenyl-2- picrylhydrazyl (DPPH•), 2, 2-azinobis-(3-ethylbenzothiazoline- 6-sulfonic acid) (ABTS), superoxide anion (O•), hydroxyl (OH•) radicals and nitric oxide (NO) assay. In addition to that, gallic acid and butylated hydroxyl toluene was used as the standard antioxidant for radical scavenger compounds. The in-vitro assays are confirmed that, the free radical scavenging and antioxidant activity of PTSB has increasing with increasing concentrations. Interestingly, among the different concentrations tested, 40μM of PTSB showed the highest antioxidant and free radical scavenging activities in all in vitro assays. In-vivo activity of PTSB also showed elevated antioxidant with decreased lipid oxidation markers. Hence the present study proved that the PTSB has potent In-vitro and In-vivo antioxidant activity with free radicals scavenger, augmenting its therapeutic potential against fluoride induced toxicity in rats.

India is committed to the goal for prevention and control of measles, mumps, rubella/ CRS (congenital rubella syndrome) by 2020. For that to achieve this goal, Measles Rubella (MR) awerness camps is being launched in the country covering all children of 9 months to below 15 years of age group. By conducting this awerness camps about 41 crore children will be covered under this campaign, The rubella vaccine, which is being introduced for the first time in India as mumps Measles-Rubella, thus, with introduction on of MR vaccine we will be protecting, MR vaccine will be introduced in all states through a wide age range MMR VACCINATION campaign targets children in the age group of 9 months to <15 years; and it replacing the current two doses of measles vaccine in the naonal immunizaon schedule for all children between 9 –12 months and 16–24 months of age immediately to MMR vaccines the future generation on of the country too. The MR campaign marks the end of several months of careful planning by the Immunization, This practical guide will enable program managers and medical to plan and implement high quality measles rubella vaccination campaigns with safety including simultaneous switch form measles to measles-rubella vaccine. Immunizaon against measles contributes to reducing under mortality and morbidity; vaccine e ecv eness of one dose of measles vaccine at 9 months of age is around 85%. vaccine e ecv eness goes up to 95% and above when given at >12 months of age; it has set the goal for MMR vaccines control by 2020, Aluminium, a common adjuvant in vaccines, is necessary to stimulate and strengthen the immunological power of vaccination, but may cause unwanted side effects, like long-lasting itching and allergies in children., Vaccination scene in India has been at crossroads as newer vaccines are being regularly licensed in the country but public sector catering to vast number of beneficiaries is extremely slow to absorb it. Many vaccination policies are openly criticized by the media and handful of disbelievers able to block the propagation of newer vaccines. This is despite clear benefits of vaccination in eradication of MMR and significant reduction of many diseases including measles-related deaths through vaccination. Main reasons for this situation are lack of awareness and demand for vaccines from the within, absence of hard-core evidence, inability to present the Further there is exaggeration of adverse events associated with new vaccines in the lay media and each serious event is blamed to the vaccine. Immunization is a proven tool for controlling and even eradicating disease. An immunization campaign, carried out by the World A successful immunization program is of particular relevance to India, as the country contributes to one fifth of global under five mortality with a significant number of deaths attributable to vaccine preventable diseases, resulting in prevention of several diseases.

In-process quality control (IPQC) tests was important to remove problems from every stage in production and maintain the quality of the In-process product with standards as specified in the pharmacopoeias. The quality of FP depends on in-process control (IPC) tests because it helps to incorporate excellence within the products. The qualitative and quantitative parameters of pharmaceuticals or biopharmaceuticals products was checked by In-process quality control (IPQC). The aim of this investigation was to provide concise information on the IPQC and FPQC (finished products quality control) tests for pharmaceutical solid dosage as per different pharmacopoeias. In the present investigation we was analyzed the quality control tests for tablets, capsules and other solid dosage forms.